Medications for treating ED available on the pharmaceutical market differ by the method of taking: oral medications, drugs injected directly into the penis, or medications to be inserted into the urethra.
Injections into the penis allow men to achieve strong erections by supplement of extra blood inflow into the penis. Injected medications usually used are: papaverine hydrochloride, phentolamine, and alprostadil (Caverject). They widen blood vessels and provide strong enough erections for sexual intercourse. These medications do not require any sexual stimulation, the erection occurs automatically. Some side effects of these drugs can be dangerous including persistent erection (priapism) besides these drugs may cause scars on the skin.
A muse system for placing a pellet of alprostadil into the urethra uses a prefilled applicator to deliver the pellet about an inch deep into the urethra. An erection is achieved about 10 minutes after insert of the drug and may last 30 to 60 minutes. The unpleasant side effects of this system are aching in the penis, testicles, and area between the penis and rectum. Sometimes this method causes warmth or burning sensation in the urethra, redness from increased blood flow to the penis and minor urethral bleeding or spotting.
The injections and systems for getting erections were common medical treatment methods before Viagra and other its alternatives appeared on the market. This latest advance for managing ED has made the treatment more effective in achieving the results even in severe cases of impotence.
Oral medications for ED such as Viagra are simple in usage, have been carefully tested for safety and effectiveness.
Viagra and other oral ED drugs belong to a class of drugs called phosphodiesterase (PDE) inhibitors. Taken before sexual activity, Viagra works by enhancing the effects of nitric oxide, a chemical that relaxes smooth muscles in the penis during sexual stimulation and allows increased blood flow.
Viagra improves the response to sexual stimulation, but it does not trigger an automatic erection as injections and systems do. Each of PDE inhibitors should be used only once a day. For all the oral medications belonging to the drug class of PDE inhibitors there are some restrictions in taking. Men with serious diseases and those who take nitrate-based drugs, alpha-blockers for prostate enlargement or high blood pressure drugs should be careful while taking ED medications. A doctor’s consultation is necessary to adjust the right dose or time schedule for taking contradictory drugs.
The other oral medication for ED is testosterone intake for those men who have hormone imbalances or who due to the aging factor have low level of testosterone. This treatment method can reduce ED in some men with low levels of natural testosterone, but it is often ineffective and may cause liver damage.
Other oral drugs such as: yohimbine hydrochloride, dopamine and serotonin agonists, and trazodone according to the results of scientific studies do not correspond to the effects claimed by the manufacturers. The reports of the most patients about improvements after taking these drugs are only placebo effect from the patient’s believing that an improvement will occur.